A research on the effects of lithium on cognitive performance
With an alpha of 0.
Lithium concentration problems
Across the central nervous system, it decreases norepinephrine release and increases serotonin synthesis. Patients had to have been free of significant changes in their medication for at least the previous 3 months. In a new paper published in European Psychiatry , it was hypothesized that BD patients treated with lithium and quetiapine following first episode mania would perform similarly across cognitive domains, including processing speed, attention, sustained attention, verbal learning and memory, visual learning and memory, working memory, verbal fluency and executive functions. Data on the latter, however, are discordant and even the causal direction is not yet clear Martino et al. A list of 16 words belonging to four semantic categories is read five times with memory being assessed after each trial. They also had to return a written informed consent form. Accompanying volumetric and spectroscopic data suggest cell loss in patients not treated with lithium that may be counterbalanced by long-term lithium treatment. As hypothesized, we found that there were no significant differences between treatment groups in processing speed, attention, sustained attention, verbal learning and memory, visual learning and memory, semantic fluency, working memory, cognitive flexibility and response inhibition. The subject is asked to point with a joystick in the direction in which the target was presented up, down, left, right. A total of subjects were included, 31 in the non-Li and 58 in the Li group, as well as 53 healthy controls.
Accompanying volumetric and spectroscopic data suggest cell loss in patients not treated with lithium that may be counterbalanced by long-term lithium treatment. The verbal subtests assess information 29 questions of general knowledgecomprehension 16 questions which focus on issues of social awarenessarithmetic 14 mental arithmetic brief story-type problemsdigit span sets of digits to repeat initially forwards then backwardssimilarities subjects asked to say how two seemingly dissimilar items might in fact be similarand vocabulary subject is asked to define 35 words.
Lithium was taken for a mean duration of 3. Other cognitive functions were unchanged in both groups. J Clin Psychiatry.
Neuropsychological testing included processing speed, attention, sustained attention, verbal learning and memory, visual learning and memory, verbal fluency and executive functioning. Copyright Physicians Postgraduate Press, Inc. J Clin Psychiatry. With an alpha of 0. Among these, lithium is the best-studied mood stabilizer. However, there are mixed reports on the effect of either of these medications on cognitive function. Infrequently, when means and standard deviations were not provided, ES was estimated from reported values of t, F, or z tests. A recently published study used standardized neuropsychological tests to compare the cognitive performance of patients prescribed either lithium or quetiapine over a month treatment period. Another scale of cognitive impairment is seen in the development of dementia. The literature search was conducted independently by 2 authors A. Study endpoints Primary endpoints of this study were the neuropsychological functioning scores in the neuropsychological tests focusing on CVLT and the volume of the hippocampus in MRI Hajek et al.
However, they are worse at processing early visual information. Background In patients with bipolar disorders, treatment strategies aim at improving the course of this often life-long and devastating disease.
Results showed that the group treated with just lithium experienced a significant improvement in verbal fluency at the 3 month and 12 month endpoints.
based on 86 review